4 6 3 win over seventh seed Ana Ivanovic.
The British number two defeated world number 27 Varvara Lepchenko 6 3 6 4 to set up a second round clash with Russia's Elena Vesnina.
Heather Watson sends world number 27 Varvara Lepchenko packing
Heather Watson secured her best win since returning from glandular fever to reach the second round of the AEGON International in Eastbourne.
Things did not begin well for the 21 year old, who dropped her serve in the opening game, but she hit straight back and then broke again Converse High Cut Shoes For Girls
to lead 4 2 before serving out the Converse Black High Tops Womens
The second set was extremely tight and Watson was under pressure for much of it but she hung on and then broke in the ninth game, saving one break point as she clinched victory on her first match point.
Watson spent two months out with the Converse Brown illness before returning at the French Open and posted her first win in Birmingham last week against Melinda Czink.
American Lepchenko was certainly a step up and represents one of the biggest victories, rankings wise, that Watson has had in her career.
Vesnina, meanwhile, pulled off a first round upset with a 2 6 6 Converse Modern Low
Also through to round two are former Wimbledon finalist Marion Bartoli and Belgium's Yanina Wickmayer, while a notable result in qualifying saw Kristyna Pliskova beat twin sister Karolina.
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